Presley Gerber's ibogaine treatment journey before his death

Presley Gerber, the 27-year-old son of supermodel Cindy Crawford and businessman Rande Gerber, died at a Los Angeles rehabilitation facility, according to reports. His death, initially reported as a suspected overdose, is under investigation, with an autopsy completed but the cause of death still pending. Gerber had been open about his battles with addiction and mental health, revealing he had tried various treatments, including ibogaine therapy in Mexico earlier this year.

Gerber's struggle with addiction and mental health

Presley Gerber had been candid about his mental health challenges and addiction struggles. In a 2022 interview on the Studio 22 podcast, he described mental health as a significant, ongoing issue in his life. By December 2025, he shared on Instagram that he had consulted up to 15 psychiatrists and expressed frustration over the lack of clear guidance with medications. Despite these challenges, he noted progress, stating he had become sober as alcohol no longer served him.

Ibogaine treatment in Mexico

Six months before his death, Gerber traveled to Mexico for an experimental ibogaine treatment. In a March Instagram post from Cancun, he detailed his preparation for an "ibogaine flood dose," acknowledging his nervousness but expressing hope for long-term benefits. Ibogaine, a psychoactive compound from the iboga plant native to Central Africa, has been explored for treating substance use disorders, particularly opioid addiction. However, it remains unapproved for medical use in the U.S. due to potential risks, including heart issues and seizures.

The potential and risks of ibogaine

Ibogaine has gained attention for its potential to alleviate withdrawal symptoms and cravings in opioid addiction, according to small observational studies. Despite this interest, the treatment is not legally sanctioned in the U.S., and researchers emphasize the need for more controlled trials to establish its efficacy and safety. The compound's intense psychological effects and medical risks, such as abnormal heart rhythms, pose significant concerns.

Why it matters

Presley Gerber's death underscores the complexities of addiction recovery and the lengths individuals may go to seek relief. His openness about his struggles highlights the importance of addressing mental health and addiction issues. While ibogaine shows promise, its unregulated status and associated risks necessitate caution. Gerber's journey serves as a reminder of the ongoing need for effective, safe treatment options for those battling addiction.

Gerber's story is a poignant reflection of the challenges faced by many in the pursuit of recovery.